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After some time, with my eyes closed, I began to enjoy this wonderful play of colors and forms, which it really was a pleasure to observe. Then I went to sleep and the next day I was fine. I felt quite fresh, like a newborn.
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At the beginning of the 1960s, here in the United States, LSD became a drug of abuse. In a short time, this wave of popular use swept the country and it became drug number one. It was then used incautiously and people were not prepared and informed about its deep effects. And then all kinds of things happened, which caused LSD to become an infamous drug. It was a troublesome time! Telephones, panic, and alarm!
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I finally decided to synthetize another sample of LSD. At the end of the synthesis, something very strange happened. I got into a dreamlike condition, in which all of my surrounding was transforming. My experience of reality had changed and it was rather agreeable. In any case, I left the laboratory, went home, lay down and enjoyed a nice dreamlike state which then passed away.
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I knew immediately that this drug would have importance for psychiatry but, at that time, I would never have believed that this substance could be used in the drug scene, just for pleasure. For me it was a deep and mystical experience and not just an everyday pleasurable one. I never had the idea that it could be used as a pleasure drug.
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I thought I would increase very cautiously the quantity of LSD in subsequent experiments to see if any of the dosages were active. It turned out that when I ingested this quarter of a milligram, I had taken a very strong, a very high dosage of a very, very active compound. I got into a strange state of consciousness.
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In old times, and also in our time among the Indian tribes, psychedelic substances were considered sacred and they were used with the right attitude and in a ritual and spiritual context. And what a difference if we compare it with the careless and irresponsible use of LSD in the streets and in the discotheques of New York City and everywhere in the West. It is a tragic misunderstanding of the nature and the meaning of these kinds of substances.
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It is true that my discovery of LSD was a chance discovery, but it was the outcome of planned experiments and these experiments took place in the framework of systematic pharmaceutical, chemical research. It could better be described as serendipity.
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It was an April day and I went out into the garden and it had been raining during the night. I had the feeling that I saw the earth and the beauty of nature as it had been when it was created, at the first day of creation. It was a beautiful experience! I was reborn, seeing nature in quite a new light.
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Persons in LSD delirium, whose condition could have given rise to such indignant condemnation, have never personally come into my sight. Such cases, attributable to LSD consumption under irresponsible circumstances, to overdosage, or to psychotic predisposition, always landed in the hospital or at the police station. Great publicity always came their way.
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They do not know very good Latin, these botanists.
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Through my LSD experience and my new picture of reality, I became aware of the wonder of creation, the magnificence of nature and of the animal and plant kingdom. I became very sensitive to what will happen to all this and all of us.
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When I discovered lysergic acid amides in ololiuqui, I realized that LSD is really just a small chemical modification of a very old sacred drug of Mexico. LSD belongs, therefore, by its chemical structure and by its activity into the group of the magic plants of Mesoameri.

Biography

Dr. Albert Hofmann (born 11 January 1906) is a prominent Swiss scientist and best known as the "father" of LSD. He was born in Baden, Switzerland, and studied chemistry at the University of Zurich. His main interest was the chemistry of plants and animals, and he later conducted important research regarding the chemical structure of the common animal substance chitin, for which he received his doctorate. Hofmann joined the pharmaceutical-chemical department of Sandoz Laboratories, Basel (now Novartis), studying the medicinal plants squill and ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals.

His research in lysergic acid, the central shared component of ergot alkaloids, eventually led to the synthesis of LSD-25 in 1938. It was five years later, on repeating synthesis of the almost forgotten substance, that Dr. Hofmann discovered the psychedelic effects of LSD after accidentally ingesting some through his fingertips on April 16 1943. Three days later, on April 19 (later known as Bicycle Day), Hofmann deliberately consumed 250 µg of LSD, and experienced far more intense effects (see: LSD for details). This was followed by a series of self-experiments conducted by Hofmann and his colleagues. He first wrote about these experiments on April 22.

He became director of the natural products department at Sandoz and went on studying hallucinogenic substances found in Mexican mushrooms and other plants used by the aboriginal people. This lead to the synthesis of psilocybin, the active agent of many "magic mushrooms".

Hofmann also got interested in the seeds of the Mexican magic morning glory species Rivea corymbosa, the seeds of which are called Ololiuhqui by the natives. He was very surprised to find the active compound of Ololiuhqui chemically very similar to LSD.

In 1962, he and his wife Anita travelled to southern Mexico to search for the magic plant ska Maria Pastora (leaves of Mary the shepherdess), later known as Salvia divinorum. He was able to obtain samples of this plant but never succeeded in identifying its active chemicals.

Dr. Pharm. (hc) Dr. Sc.Nat. (hc) Hofmann is Member of the Nobel Prize Committee, Fellow of the World Academy of Sciences, Member of the International Society of Plant Research and the American Society of Pharmacognosy.

He has been author of over 100 scientific articles and has written (or co-authored) a number of books, including LSD, My Problem Child, which is partly an autobiography and describes his famous bicycle ride.

Further reading

* Wasson, Robert Gordon / Hofmann, Albert / Ruck, Carl A. P. (1978): The Road to Eleusis: Unveiling the Secret of the Mysteries (Ethno-Mycological Studies, No. 4). Harcourt. ISBN 0151778728
* Schultes, Richard Evans / Hofmann, Albert (1980): Plants of the Gods: Origins of Hallucinogenic Use. Random House / Arrow. ISBN 0091416000
* Hofmann, Albert (1981): LSD, My Problem Child. McGraw-Hill. ISBN 0070293252
* Hofmann, Albert (2001): LSD - Mein Sorgenkind. Klett-Cotta. ISBN 3-608-94300-5

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